Tessa
Tessa is a Bayesian model to integrate T cell receptor (TCR) sequence profiling
with transcriptomes of T cells. Enabled by the recently developed single cell sequencing
techniques, which provide both TCR sequences and RNA sequences of each T cell concurrently,
Tessa maps the functional landscape of the TCR repertoire, and generates insights into
understanding human immune response to diseases. As the first part of tessa, BriseisEncoder is
employed prior to the Bayesian algorithm to capture the TCR sequence features and create
numerical embeddings. Please refer to our paper for more details: 'Mapping the Functional
Landscape of TCR Repertoire.',Zhang, Z., Xiong, D., Wang, X. et al. 2021.